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Antofagasta is a city located in northern Chile, specifically in the Antofagasta Region. Antofagasta is a major port city and serves as the regional capital. Antofagasta hugs the Pacific coast and is known for its breathtaking sea views. The city is a gateway to the Atacama Desert, one of the driest places on Earth. With a thriving mining industry, Antofagasta is like the tough, gritty cousin of Chile’s coastal cities.